There is a lot of science here that I am sure that others on this forum are more qualified to answer, but I will take a stab at it to keep the thread going and (hopefully) get some more intelligent feedback.
This all comes down to ballistics. This is all relative to the shape of the projectile as well as the twist rate on the barrels, rifeling, etc. It also has to do with whether your wind is a cross-wind, diagonal, or a head/tail wind as all can affect the travel of the projectile differently depending on the ballistic properties of that projectile. I hesitate to say that it is just the Ballistic Coefficient (BC) as that is only relative to the drag, not necessarily the accuracy as you were asking.
Anecdotal evidence, pretty much all of the guns that placed at RMAC were 30cal. The 30cal buck the wind better than smaller calibers because there is more mass in the pellet for the wind to push around. The 0.177 you have will suffer in the wind worse than the 0.25cal, unless there is something else jacked up with your 25cal, like the twist rate, etc.
I hope that this helps a little.