Slug weight, twist rate and fps?

Is there a correlation between the three to help finding the best pellet. Like a 30 grain pellet work best in a 1 in 16.1 shot at x speed?

I don't know enough about internal ballistics to figure this out, but I see FX comes with standard and heavy superior liners for different slug weights. 

For my particular setup - Leshiy 2, .25/450mm barrel, 30-34gr slugs. With the current tune I am shooting the 30gr slugs at ~950fps, the 32gr around 930 and the 34gr around 920. The 34 grains are pretty bad at 920. The 32gr and 30gr are showing promise at their respective speeds but I need more distance testing time.
 
Exactly. 😉

Similarly, I am shooting my own hand cast HP's at normally 30's to 960's and have fantastic accuracy. But only after I removed the choke. it was terrible before. 

Fx slugs crush down similar to a pellet, so a choke works.However With normal slugs, chokes cannot help, but can really hinger accuracy. ot to mention lead up much more rapidly.

Why, because you either slug the bore and size to the groove dia which is not correct for the choke,or you size to the choke and the slug is not stable traveling down the bore until it hits the choke. And can very well be skewed when it enters the choke. Not good for accuracy. I will work some times, but not often. Sorta like Blind Hog Finds Acorn.