MORE POWER//SMALLER CALIBERS

It is very plausible for sure. But I am no expert in ballistic coefficients or ballistic physics in general so I will leave that for others. I for one was thinking of getting larger calibers, but have since changed my mind and I think I will stay in .25 or less. I can tell you my next PCP will probably be in .177. 

Good to see you back and active in the forum again my friend. 
 
For general pesting I stick with 25 and under as you have mentioned the power output now is very generous. I am definitely looking at a 177 slug spitter. On the local permissions I have no reason to shoot anything larger than a 22 and have been in situations where a 177 would have been a much better option with a slug. Only time I have gone with a 25 was to take a pesky yote harassing the chickens etc. With slugs and the right shot placement he was DRT, farmer was happy and asked me to look out for more. Only reason I want a .357 is local hunting laws require it to hunt bigger game.
 
Anything that increases power in a smaller caliber will also increase power in a large caliber...as well as bc...so all calibers remain in their rightful place. Just as you say there is a correct tool for every job, and you certainly won't be shooting a .357 inside a barn at rats, nor will you shoot a .177 slug shooter in a barn at rats...nor will you shoot a .177 at coyote from 100 yard...you see where I am going here? Chill out with the 'this caliber is going to replace this caliber!' talk...because it ain't happening chief.
 
I would love to see more in the smaller calibers just because there is opportunity for better BC's. One of the issues becomes diminishing return on power from a given pressure. It takes more pressure to move a smaller projectile since there is less area to push on. It takes more volume of air to push a larger projectile. The best balance I am seeing in airgun pressure levels seems to ba around the .25 cal. 

For example with most given tunes on my Impact, If I change barrels without changing settings I get the best velocities and sometimes even shot count in .25.

Is anyone having a different experience?
 
I have to disagree. Right now there is .177, .20, .22, .25, .30, .357, .45, .50. There's a choice for everyone and task. When I was a kid there was .177 and .22 - the choices only get bigger, not smaller. Unless a particular caliber (ahem .20 - don't hate me) that is really niche and it becomes hard to obtain (or have a decent selection of) ammo for it.

Power's fun but not everything. I got into PCP for simple, consistent and precise power. But just by grabbing any of 6 or 7 airguns I can go from 6fpe to 800+ fpe. 

One other to consider is energy transfer to the target and pass through (if you're a hunter). My guess would be if you put a 60 fpe .22 up against a 60 fpe .30, the .30 will be able to transfer more energy to the target.

edit:

I just thought to add that if we are talking purely longer range target shooting I'll take a smaller caliber that can push serious power.