Hi a crossman 2240 is a 22 pistol , which can get up to 14fpe but most should be around 12fpe
so it should shoot 18 grains like 600fps , so somehow your gun is way to low unless you shooting 33 gr jsb at 454 which would be 14fpe
so to answer question , 6 fpe can kill a squirrel with a good shot placement , The main thing is if you can group 5 of 5 shots under 1/2 inch then this is the range you should shoot a squirrel , I have killed squirrels with a 12fpe gun at 65 yards , but the gun is lazer accurate ,
shot placement is everything , with low power like this you have to be spot on , when you did chrono what weight you using ???? if it is really 454fps was your CO2 FULL?