If you mean a powder-burning .22 rifle, I'd say - a Ruger 10/22, I have several (for me and my sons). But, I also have a Ruger American .22 Bolt Action with a Q Erector silencer on it - probably my favorite .22. It's accurate and is as quiet (maybe quieter) than any of my pellet guns with subsonic ammo - and those rounds packs a punch with its heavier than a pellet bullet. It will shoot any LR round I feed it, whereas my auto 10/22's won't cycle sub sonic rounds.