New member here, and I probably should't post to this thread....but I can't help it.
I was raised in Louisiana but have lived in Colorado for the past 15 years. While I haven't done everything, I've shot bison at 40 yards and prairie dogs at 800.
IME, more whitetail are wounded with a .30-30 at 40 yards than with a 6mm Rem at 400. Almost anybody will take a shot at a 40 yard whitetail because "no way to miss", and they do. In your face encounters generally encourage rapid, for better or worse, response.
Increase the distance by a considerable margin, and the nimrods know it's simply too far, and don't shoot. If they're even less talented than that a complete miss is practically guaranteed. But, for those with the right equipment and an intimate knowledge of its capabilities, well....this is the "comfort" zone. The critter's not going to hear you slide the gun into place, nor see you doing the same. Since you can see it so far away, your FOV must be pretty good, so you have all the time in the world to set up the shot. A much calmer situation than a deer popping out of the jungle at 30 yards.
There's actually time to consider the circumstances of the shot.
I've done many of both. Give me time and distance every time.
Ethics are a subjective thing. Landing a projectile where it needs to is completely objective.