Short answer no, long answer yes.... Lol let me explain. No pellet size is inherently more accurate than another. However the bigger the pellet the better the BC which means it will drift less in the wind. So if you are shooting 10m then perhaps 177 is best, hunting out to 50 yards maybe 22 is best then you want to kill rock chucks out to 75 or 100 yards a 30 cal starts to be the answer. So you see the caliber you choose really aught to be picked by the way you intend on using it. I prefer a 25 cal for all my hunting needs because it kills everything from squirrel to coyote out to some serious range especially if I use slugs. When I shoot in my backyard I use 177 and they are Lazer accurate.