I had the Leupold 45x45 competition scope. Got rid of it (sent back to dealer as it had a loss of focus as I tracked around the card) and bought a Sightron Sll 36x42...hmmm, it was OK but not quite 'there'.
Bought the Sightron Slll ED 45x45 and it's absolutely lovely. Crisp, clear, tracks superbly, holds it's focus.
Have tried other benchrest club members vari power setups and they can't beat that Slll 45x45 for the clarity of the target.
Plus, as others mention..it's not a boat anchor.
An older member of the club (I'm only 75) looked through my new scope, said "Wow", and next day bought his own Slll ED 45x45.
Yes, hard to beat a good fixed power. Maybe if outdoors and fighting mirage you might want a vari so that you could wind the power back a bit.
For me, shooting only indoors, it's the fixed power all the time.