That's the nature of many .25 cal. slugs, unfortunately. Lol Bubblerboy and I have been talking about this exact thing for a long time. Any little change, and I mean any.... grip on the gun, pressure on the gun, any torque on the gun, variations in air pressure, etc... can often cause a slight shift, which at 100yds can mean inches. When I was testing slugs in my 600mm Crown, I had this happen all the time, 8-9 shots that were perfect and then a flier. I don't know if your shooting out of a magazine but that can be a cause for it too. A single shot tray is always better for this type of testing. Eliminate all the variables you can! Maybe try them a little slower? I always preach shooting slugs pretty fast but all of the Nielsen slugs I've tested usually shoot best between 900-1000fps and more specifically about 920-960fps. Maybe back it off to something like 970fps with the valve up front wide open and then slowly lower the velocity with the valve until you find the sweet spot. Shoot 5 shot groups until you see the groups shrink and then test that velocity more thoroughly. All guns are obviously different but I can tell you that with my Impact MKII, every single slug I've tested for Nick, like 30 different slugs, I got to shoot very well! Sometimes it takes a long time, a lot of tuning and can get frustrating but they all seem to shoot great. The dish base slugs shoot very well but in the Impact, the flat base, large hollow point slugs are generally easier to tune and shoot better. I hope you get it figured out, please let us know when you do!
Stoti