LOU,
While I suppose several of the other suggestions could be variables,
what you just brought up about thread-precision is a definite factor..
I have 6 PCP guns [5 rifles and 1 pistol] and use DonnyFL setups on all of them..
5 out of 6 guns use adapters, and all of them use the same 2 suppressors..
5 guns are .22 cal, and 1 gun is set up as a .25 cal.
All adapters and both suppressors have a max dia for .25 cal.
If I shoot each gun 'naked' - no adapter, no suppressor, I'll see a certain POI.
If the adapters are threaded on, I don't think I've ever noticed a POI difference..
But, when the suppressors are added - and Yes, the male/female threads are Very Nice,
however, they're a course thread, not a fine thread, so, there will be room for 'error'..
While installing / threading the suppressors on, there is a noticeable amount of play
until' the very end when the suppressors' back caps bottom out on the end of the adapter..
That is when and only when there is absolutely no play..
Repeating this doesn't guarantee that the suppressor and adapter meet 100% the same every time though..
And I think that part is what some people don't always take into consideration..
So in the case of thread-play Only, I've tried using Yellow 'Teflon' / Thread tape on the adapter threads,
and the tape does exactly what it's supposed to do - it takes up the gaps between threads,
and tightens things up a bit more.. When screwing things together after that, there's a big difference.
[Threading things on/off anyways] After doing that, I didn't notice having to adjust as many 'clicks' as before..

Sam -
PS: On my direct to barrel setup, [Kral Puncher Breaker] I did notice a little bit of 'barrel droop'
from the added weight of the suppressor
and that is normal..
To help with that, I added a few rubber grommets to the front shroud clamp/ring where the bbl passes through..
It is not too loose, or too tight, but just enough to keep the bbl 'free floating', but not droop.. Cheap / Effective.
As for POI shifts due to using suppressors - Centercut brought up some good info, points, and improvement
Since the expelled air is obviously going to be different w/ vs. w/o the use of suppressors,
I've also noticed that going with one dia size up from the round being fired has always worked like a charm..
*That's why I use the .25 cal suppressors on all of my .22's and not a 22 dia on them..
Tighter space when the pellets exit, so more apt to effect them
Some people argue against doing that - when it comes to sound lowering efficiency,
but IMO, I'm much more concerned about accuracy / precision in the end..