Does an after-market moderator affect POI? In other words, will I have to re-chrony, zero, and range my Wildcat .25 MKI after installing a DonnyFL SUMO moderator? Thanks 
The POI change has barely anything to do with harmonics or disruption of airflow (except when it’s clipping). The added weight causes the barrel to bend more and therefore is the biggest influence on the POI shift, this means the POI will move down. The better the barrel is supported (by a barrel band for example) the less the POI shift will be noticeable, a barrel band has other drawbacks but that’s not the question here. Attaching a lighter moderator will also decrease the vertical POI shift compared to a heavier moderator.
You’ll only need to re-zero the gun, there rest stays the same if the moderator is attached properly.
Surely, you jest?