Interesting discussion... I have an Airforce Escape in .22 cal and an Airforce Condor in .25 cal. The rifles are mostly used for hunting and I am just now trying to decide if I need both?
The .22 cal, even at 50+ ft lbs is back yard friendly with one of Geo's newest LDCs, and I can turn the power way up beyond that if necessary with a quick twist of the power wheel. Currently shooting JSB 25.39 Monsters, but can go to heavier pellets or slugs easily moving into the weight range and power of many .25 cals. This is my goto hunting rifle and I am comfortable that if hunting small game, and the opportunity for something larger happens, I can take the shot. (with proper shot placement of course)
In the state of GA, (Airgun friendly state) any airgun can be used for small game, but .30 cal or larger is necessary for large game, including Turkey. It makes a lot of sense to sell the .25 cal Condor and purchase a .30 cal, or .357 and I have all the bases covered.
If I could only have one rifle, I would probably go with a .30 cal for overall versitility, but each situation is different. In the case of the .22 cal vs the .25 cal, I have to lean towards the .22 cal (at least with powerful airguns like the Airforce line)