Hunting and shooting. I don't want to shoot my power burners. Can't find ammo.
I really like my .25s for getting that extra energy into a target while shooting pellets. The cross section of a pellet is found by multiplying pi times the radius squared. If you do the math you will see a .25 has a whole lot more surface than a ,22.
I don't shoot slugs because I like the additional safety pellets offer with their reduced range.
Or machine a Lilja 22lr Match grade barrel and use pulled Eley Tenex Rimfire bullet heads.
If you have fat fingers .25 are easier to grab and load than .22s.
More FPE for FPS vs .22.
.25 kills vermin more deader than.22 can kill them.