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It varies greatly.
How long does a CO2 pellet gun last before the seals go bad?
The oldest Co2 gun I currently own is a Crosman 112 I've 'personalized' because they're such incredible airguns. They were produced from 1949 through 1953 or 54. While refinishing it in DuraCoat about 15 years ago I replaced all the seals, and she still holds a charge for months at a time. As to how long a Co2 gun lasts, considering this one is at least 65 years old, now looks better than new, and outshoots any Co2 pistol produced in 2019, I'd guess a good Co2 gun can last 2 or 3 human life-times.
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BTW, to any little-red-ballers waiting for an excuse to cast anonymous aspersion to the effect of "untrue", "inaccurate", or "hot air n gasman", feel free to do so IF you can show me a currently-produced .22 Co2 pistol that can average .58" center-to-center groups at 25 yards, produce over 500 FPS and 8 foot-pounds of muzzle energy, and last multiple lifetimes. I don't make fantastic claims without proof... ever. Just because a little-baller doesn't want to believe something 'he' isn't capable of, doesn't make it any less true.
Heres a .177 version Model 111 I also personalized. It broke 550 FPS, 6 foot-pounds, and averaged .69" c-t-c 25 yard groups.
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Neat old air guns.