.177 will work although over-all a .22 will produce less maim shots and that trend continues as caliber increases .. we demand good shot placement but sometimes 'you take the shot' you got ... .22 will do better 'but' .177 is very easy to get cheap ammo for still locally .. so i look at it as i can use .177 for close in pesting which most of it is anyway .. if you got that long shot though, at 50 yards into the treeline you better grab something more substantial like a .25 if you want a pretty sure clean kill ..
Honestly, this has not been my experience. With equally good placement, I have found the .177 just as effective. That said, the math doesn't lie, and there will be a distance at which the .22 will, for example, punch through the heart/lung area, where the .177 might not make it through the initial bone. But, whatever that distance is, it is beyond my comfort level anyway. And it is definitely beyond my 35 yard pesting zone at home.
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