I have 2 Crowns, a Crown Continuum in .22 and a gen 1 in .25, that I move back and forth between .22 and .25 and between 380mm, 600mm and 700mm barrels. It is no problem at all. As Mike says above, loosen the two screws on each side of the front end of the breech block and remove the old barrel, replace the new one and then swap out the probe. I found that going between the .22 and .25 did not even require any change to the reg or hammer spring. Of course, going to .30 may be different, or you may simply choose (as I did) to make adjustments because you want more or different velocity/power levels in the new caliber. I found that setting up for the maximum that I wanted in the larger caliber worked fine with the smaller caliber since I just shoot it at a lower level on the Power Wheel. Even if you do want to change the settings every time it really is quite easy to do.
Chris