To my understanding, the guns are the same whether .22 or .25. Perhaps adjusted differently. That's the beauty of the Avenger, it's adjustable.

Running at higher pressures isn't always your friend. The increased reg pressure can make the gun a tad more unstable (vibrate more) during the shooting cycle. I have my Impacts tuned way down, in the 110 bar range for best accuracy. Only got my Avenger a few weeks ago, and intend to use it as a slug gun. All I need to do is turn up the reg pressure and increase the hammer spring to max (about 2700 PSI and 5.5 turns on the hammer screw according to Steve at AEAC) to get max power out of the gun. Hoping to drive a 24 grain slug well over 900FPS in .22.

Might want to watch AEAC's Avenger tuning video. So, in my opinion, no, there's really no advantage to running a .22 at the higher pressures unless you have a specific reason like slugs. My experience for best accuracy for pellets is 850 to 930 ish feet per second with the pressures set as low as possible for best efficiency. Accuracy and efficiency seem to go together, at least from what I've seen.
 
According to the parts schematic, the hammer spring is the same for .22 and .25 (and different in .177). However, the .25 has a spacer/washer added to the hammer spring (that the .22 does not have).

I assume the barrel port size will be caliber appropriate (and smaller in .22 when compared to .25).

Do you have a .25 in your possession? The schematic shows the set screw that lives over the port to be M6. M6 x 1.0 is the typical/most common M6 thread pitch (but I do not know if 1.0 pitch is the correct size for the Avenger's fastener). The tap drill size is 5mm for M6 x 1.0. That screw is the same for all 3 calibers. I would say it's safe to assume the block's port is the same size for all 3 calibers. Air Velocity Sport made a teardown video. Drilling this hole larger, and replacing with a larger set screw was one of the mods discussed.

Hopefully this helps.

Edit: all of the above is in the context of the plastic or wood stocked Avenger full-length-rifle. I have no information related to the bullpup, and I have no idea about what parts are shared between the two platforms.
 
No need to drill out threads just open it up with a carbide burr in a rotary tool like this. I've never come close to running the battery down even on long jobs.

Go slow with a firm grip and a light touch. Don't try grinding stones on aluminum they just pack up with aluminum and become useless.

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