On a couple of big bore posts deciding pros and cons of a couple different guns I was researching in 357, more than one member asked why don't I get a 45? Ok, I know very little about projectiles in this range but I'm hearing that 357 guns I was checking out shot 140-160g slugs for 250 FPE. I can only extrapolate that 45 shoots what? 250- 300g? for about 400-450 FPE? Bear with me if I'm off on these values. So I see it as this: what can the 357 ethically kill up to? I would suspect 45 for maybe a big buck or bear, elk so forth. I'm not hunting bear, elk. No intention of either at this time. Now the 357 was my preferred size because of twice the shot count per fill and cheaper ammo per shot. If I need to , the 357 will take out a coyote or hog if necessary. I know their is more to this game than this so I'm all ears.