Personally, I would go for head shots if I was eating meat from a small animal as long as I was using lead pellets. Do not want the lead residue in the meat. H&N makes the Rund Kugeln round ball that is copper coated that gets rid of lead residue issues in meat, but my Lonestar does not shoot them accurately. If I was only going after very small animals like squirrels, quail, rabbits, pigeons, doves, etc., and doing only head shots, then I would use a high powered .177 cal and heavy pellets with a high BC for accurate long distance shots.
I am more worried about the lead toxicity that affects me than the meat damage the pellet will cause to an animal, if the pellet is hitting any meat I would be consuming. Take it from a guy that had to be detoxed from mercury he got in dental fillings. In a heart/lung shot on a mule deer, I get rid of the heart and lungs as it is full of lead fragments from my expanding soft nosed bullets, with up to half or more of the lead gone from the recovered bullet. Lead free pellets should be used if going for body shots on small animals you intend to eat.