I have no experience with slugs, but I read the comments on choked barrels, or not. In .22 RF, there are some excellent barrels of both configurations. The best RF barrels I've owned have been choked, not sure if that means much here, but thought I would mention it. As already stated, the right slug/barrel profile combination is critical. Again, assuming some general characteristics that probably apply to both air and cartridge rifles. I expect, once the slug and barrel makers do their work on the best applications, we will see slug rifles that not only outperform their pellet cousins, but fully equal cartridge rifles. By removing the variables of powder, primer, and case, it just seems that it has to be true.