Your question is probably not directed to me but I'll offer my take on it.
Matt and the Air Hunters no doubt have tried most, if not every, sensible combination of slug weights, barrel lengths and velocity.
Twist rates were probably developed around the weights that performed the best during testing.
That's not to say that you are limited to only shooting that specific weight at that velocity. You might find a combination of other weights and velocities that work well enough.
I have a few hundred 19 and 21gr slugs, as well as some recently ordered 23gr slugs. You can bet I'll try the lighter slugs as opposed to throwing them away. Maybe they'll be decent for close to mid-range targets.....who knows.
But consider that in 22 caliber, the lighter slugs are very short, which probably isn't advantageous no matter how you look at it.