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Self healing targets and big bores

Dumb question of the day...

I've read enough to know that the rubber "self healing" targets commonly found in stores now are a bad idea for small bore airguns, unless you like targets that shoot back. But what about big bores like the Texan or DAQ .45? It seems like these guns would have sufficient energy to be safer, much more like shooting one with a .38 special. Thoughts?